InChI=1S/C21H39N7O12/c1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35/h4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28)/t5-,6-,7+,8-,9-,10-,11+,12-,13-,14+,15+,16-,17-,18-,21+/m0/s1, N-[(1S,2R,3R,4S,5R,6R)-3-carbamimidamido-6-{[(2R,3R,4R,5S)-3-{[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy}-4-formyl-4-hydroxy-5-methyloxolan-2-yl]oxy}-2,4,5-trihydroxycyclohexyl]guanidine, CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]1[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](NC(N)=N)[C@@H](O)[C@@H]2NC(N)=N)O[C@@H](C)[C@]1(O)C=O. Tetracylines: Structure and Mechanism of Action | Antibiotics, 6 Antibiotics used in Inhibitors of Protein Synthesis, Chloramphenicol: Structure and Mechanism of Action | Antibiotics. Streptomycin, the first antibiotic to be discovered by random screening of soil organisms, is predominantly active against enterobacteria and M. tuberculosis. It binds to the small 16S rRNA of the 30S subunit of the bacterial ribosome, interfering with the binding of formyl-methionyl-tRNA to the 30S subunit. Resistance to streptomycin can occur by this mechanism since this agent binds to a single site on the 30S subunit of the ribosome. The schematic representation of the mechanism of streptomycin dependence is shown in Fig. Aminoglycosides like Streptomycin "irreversibly" bind to specific 30S-subunit proteins and 16S rRNA. The antibiotic streptomycin is widely used in the treatment of microbial infections. Killing the bacteria by interrupting the bacterial cell wall formation. 2007 Feb;63(4):1096-106. [, Kenney TJ, Churchward G: Cloning and sequence analysis of the rpsL and rpsG genes of Mycobacterium smegmatis and characterization of mutations causing resistance to streptomycin. 341-350. Foreign Title : Sur le mécanisme de l'action de la streptomycine. Epub 2007 Oct 13. Streptomycin is an aminoglycoside antibiotic produced by the soil actinomycete Streptomyces griseus. Ethambutol, Pyrazinamide, Thioamides, Cycloserine, Para-aminosalicylic acid, Streptomycin, and Clofazimine are possibly effective. It consists of three components linked glycosidically (by ether bonds): (i) Streptidine (inositol with two guanido groups). Action de la streptomycine sur les bactéries. Mol Microbiol. Highly purified streptomycin is nontoxic when given in small doses, but it appears to have a cumulative detrimental effect on nervous system when, given as a medication over long periods of time. Streptomycin induced K + flux is MscL-dependent. Know how this interaction affects the subject drug. The peak serum concentration in individuals with kidney damage should not exceed 20 to 25 mcg/mL.The concurrent or sequential use of other neurotoxic and/or nephrotoxic drugs with streptomycin sulfate, including neomycin, kanamycin, gentamicin, cephaloridine, paromomycin, viomycin, polymyxin B, colistin, tobramycin and cyclosporine should be avoided.The neurotoxicity of streptomycin … 2007 Jul-Aug;1769(7-8):462-71. The mechanism of inhibition of protein synthesis by streptomycin is schematically shown in Fig. Streptomycin, like other aminoglycosidic antibiotics (e.g., gentamycin, neomycin, kanamycin, tobramycin), inhibits protein synthesis in bacterial cells by binding to the 30S subunit of ribosomes. New England Journal of Medicine 363 (9): 852–863. Start studying streptomycin. X-ray crystallographic structure of the 30S ribosomal subunit with bound drug (purple, space-filling model , at center) protein secondary structure elements such as alpha-helices in bright green, and the RNA phosphodiester backbone shown in orange (and the ladder of base pairs in dark green and blue) “New Therapeutic Approaches to Mendelian Disorders”. For the treatment of tuberculosis. Irving H. Goldberg, Mode of action of antibiotics, The American Journal of Medicine, 10.1016/0002-9343(65)90094-X, 39, 5, (722-752), (1965). Disclaimer Copyright, Share Your Knowledge A severity rating for each drug interaction, from minor to major. It has been found that streptomycin-susceptible bacteria may become resistant to the antibiotic by a single step mutation. Not been fully identified, antibiotics, streptomycin an d kanamycin are of... Called streptomycin- dependence STANIER RY are examples of aminoglycosides GORINI L. streptomycin, and the CODE of producing Derivatives... 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